超声评价2型糖尿病肾病患者肾小球滤过率对颈动脉血管重构的影响

摘要

目的：探讨应用超声评价2型糖尿病肾病患者肾小球滤过率( GFR)对颈动脉血管重构的影响。方法将2011年11月至2012年11月深圳市盐田区第二人民医院收治的73例2型糖尿病肾病颈动脉粥样硬化患者按照GFR不同分为两组：GFR≥60 mL/(min·1.73 m2)为A组38例,GFR<60 mL/(min·1.73 m2)为B组35例；另外,选择同期收治的40名健康志愿者作为对照组(C组)。应用高频超声测量受试者颈动脉血管总面积,计算重构指数( RI)。结果 B组血管重构的发生率大于A组,差异有统计学意义(P<0.05)；A以无重构为主。 B组负性重构的发生率41.67%(25/60)与C组7.14%(1/14)比较差异有统计学意义(P<0.05)。结论超声可以准确、快捷地监测2型糖尿病肾病颈动脉粥样硬化患者颈动脉血管重构情况。%Objective To observe the impact of Ultrasound in evaluation on impact of glomeruar filtra-tion rate( GFR) to carotid remodeling for type 2 diabetes nephropathy patients. Methods Patients with type 2 diabetes nephropathy were divided into 2 groups according to the level of GFR:38 with GFR level more thanorequalto60mL/(min·1.73m2)ingroupA,while35withGFRlevellesstha60mL/(min·1.73 m2 ) in group B;40 healthy subjects were enrolled as group C. All subjects were examined with high-frequen-cy ultrasound. When atherosclerotic plaque was found,the total vessel area and lumen area were measured, and the remodeling index was calculated. Results The remodeling rate of carotid atherosclerosis in group B [(85. 71%(30/35)) was higher than that in group A[39. 47%(15/38); all P<0. 05),and in group A and B was higher than that in group C[17. 50%(7/40; both P<0. 05). The positive remodeling rate was higher than in all the groups,but positive remodeling is the main type of group A and B,vesels without re-modeling was the main type of group C;there was statistical difference of negative remodeling rate between group B and C[41. 67%(25/60) vs. 7. 14%(1/14),P <0. 05)]. Conclusion High-frequency ultra-sound can accurately and quickly monitoring type 2 diabetic nephropathy patients with carotid atherosclerotic carotid artery vascular remodeling situations.