抗菌肽在肿瘤方面的研究进展

摘要

抗菌肽是天然免疫系统中的一种小分子多肽，其相对分子质量小、热稳定性强、水溶性好，而且结构简单、功能诸多。抗菌肽除具有广谱抗菌活性外，还有抗真菌、抗病毒、抗肿瘤及促进创伤修复等作用。目前大部分化疗药物往往同时抑杀肿瘤细胞和正常细胞，因此关于抗菌肽抑杀肿瘤细胞的探讨成为目前研究的热点。近年研究发现，抗菌肽抑制肿瘤细胞作用的机制各异。%Antibacterial peptide is a kind of small molecular peptide in the natural immune system .It has small molecular weight,good thermal stability and is water soluble.In spite of simple structure,it has many functions.Besides its broad spectrum antibacterial activity,it also possesses additional functions inclu-ding antifungal,antiviral,antitumor and promoting wound healing.At present,most of the chemotherapeutic drugs could kill tumor cells as well as normal cells,therefore,the discussion about antibacterial peptides kill-ing tumor cells is becoming a hot spot in current research field .It′s discovered in recent years that the mecha-nisms of antibacterial peptides inhibiting tumor cell functions are all different .