吸烟与年龄相关性黄斑变性关联性的研究进展

摘要

Age-related macular degeneration( AMD) is a kind of senile degenerative disease of macular. Along with the aging population increasing,it has become one of the main blinding diseases. It is influenced by environmental and genetic factors,and cigarette smoking is one of the most important environmental factors and also the only controllable factor. The mechanisms include oxidative stress,antioxidant depletion,comple-ment activation and vascular changes. Cigarette smoking can lead to the damage of retinal pigment epithelium cell′s normal physiological structure,functional damage and the number decrease,forming dry AMD( atrophic AMD) which has no effective treatment so far.%年龄相关性黄斑变性( AMD)是一种黄斑区的老年性退行性病变,随着我国人口老龄化的日益加重,本病已成为致盲的主要眼病之一。受环境与遗传基因的综合影响,其中吸烟是最重要的环境因素,也是唯一可控的因素。吸烟导致AMD发生的可能作用机制包括氧化应激,抗氧化剂消耗,补体活化和血管改变,引起视网膜色素上皮细胞的正常生理结构破坏、功能损伤和数量减少,形成干性(又称萎缩性) AMD,而目前尚无有效治疗方法。