老年2型糖尿病患者动脉粥样硬化的危险因素分析

摘要

Objective To discuss the risk of atherosclerosis for elderly patients with type 2 diabetes mellitus(T2DM). Methods Total of 560 cases with T2DM admitted to Cardiovascular Medical Center of Huizhou Third People′s Hospital from Jan. 2011 to Dec. 2012 were included,according to the existence of atherosclerosis,the patients were divided into simple T2DM group(340 cases) and T2DM + atherosclerosis group (220 cases). The general information,fasting blood glucose,glycosylated hemoglobin,homocysteine and blood pressure and lipids of the two groups were analyzed and compared,and atherosclerosis risk factors for elderly patients with T2DM were analyzed. Results The multiple Logistic regression analysis showed, fasting glucose(OR=1. 373,95%CI 1. 051-1. 945),triglycerides(OR=2. 658,95%CI 1. 146-4. 925),gly-cosylated glucose protein(OR=1. 943,95%CI 1. 042-3. 287) were independent risk factors for atherosclero-sis. Conclusion There are various risk factors for atherosclerosis of patients with T2DM,which should be controlled along with blood glucose control,so as to effectively prevent the occurrence of macrovascular dis-ease,and ensure the patient′s life safety.%目的：探讨老年2型糖尿病(T2DM)患者动脉粥样硬化的危险因素。方法选取2011年1月至2012年12月惠州市第三人民医院心血管医学中心收治的560例T2DM患者为研究对象,根据患者是否出现动脉粥样硬化分为单纯T2DM组(340例)和T2DM+动脉粥样硬化组(220例)。对比分析两组患者一般资料,空腹血糖值、糖化血红蛋白、同型半胱氨酸以及血压和血脂等相关指标的差异,并分析老年T2DM患者动脉粥样硬化的危险因素。结果多因素Logitic回归分析结果显示,空腹血糖(OR=1．373,95%CI 1．051~1．945)、三酰甘油(OR=2．658,95%CI 1．146~4．925)、糖化血糖蛋白(OR=1．943,95%CI 1．042~3．287)是影响动脉粥样硬化发生的危险因素。结论老年T2 DM患者动脉粥样硬化的危险因素较多,因此临床对患者进行血糖控制的同时需要对患者的危险因素进行相关控制,从而有效预防大血管病变的发生,保证患者的生命安全。