微RNA-181 b在成人急性白血病中的研究进展

摘要

急性白血病是造血干细胞恶性克隆性疾病，微 RNA（miRNA）在其发生、发展过程中有重要的基因调控作用。 miR-181 b在急性白血病和其他多种恶性实体肿瘤中表达上调，具有癌基因作用，不仅参与肿瘤细胞增殖、凋亡、侵袭和迁移等调控，同时还与药物敏感性及预后密切相关。因此， miR-181b的表达改变可作为预测疾病进展及预后的重要生物学指标。%Acute leukemia is a malignant hematopoietic stem cells clonal disease , and microRNA (miRNA) play a gene regulating part in the process of its occurrence and development.The miRNA-181b has been found to function as oncogenes in acute leukemia and variety of other malignant solid tumors ,which not only is involved in regulation of tumor cell proliferation,apoptosis,invasion and migration,but also is closely related to the drug sensitivity and prognosis.Therefore,the expression changing of miRNA-181b can be used as important biological indicators of disease progression and prognosis.