免疫反应在非酒精性脂肪性肝炎中的作用

摘要

非酒精性脂肪性肝病是全球最常见的肝脏疾病，发病率逐年增长，其中10％～20％为非酒精性脂肪性肝炎（ NASH）。 NASH患者有进展为肝纤维化、肝硬化、门静脉高压症、肝衰竭和肝细胞癌的风险。免疫细胞在NASH发病中起重要作用，固有和适应性免疫系统均参与了 NASH 的发生、发展。病原体相关分子模式和损伤相关分子模式可以激活各种模式识别受体，导致炎症，促进NASH的发生、发展。%Non-alcoholic fatty liver disease(NAFLD) is the most common liver disease worldwide,and the incidence continues to grow.It is thought that around 10%-20%NAFLD are non-alcoholic steatohepatitis ( NASH) .Patients with NASH have the risk of developing fibrosis and cirrhosis leading to portal hyperten-sion,liver decompensation,and hepatocellular carcinoma.Immune cells have an important role in the patho-genesis of NASH.Both the innate and adaptive immune systems contribute to the development of NASH . Pathogen-associated molecular patterns and danger-associated molecular patterns are known to activate a vari-ety of pattern-recognition receptors that result in inflammation ,which promotes the development and progress of NASH.