聚乙二醇与磷酸钠盐清洁肠道安全性和有效性的Meta分析

摘要

目的：系统评价口服聚乙二醇与口服磷酸钠盐清洁肠道的安全性和有效性。方法通过检索荷兰医学文献（ Embase）、美国国立医学图书馆（ PubMed）、Cochrane临床试验数据库等，收集口服聚乙二醇清洁肠道与口服磷酸钠盐清洁肠道的随机对照临床研究，提取资料和评估方法学质量，采用协作网提供的RevMan 5．2软件，应用固定效应模型分析，对符合纳入标准的12个研究进行Meta分析。结果聚乙二醇在不良反应发生率低于磷酸钠盐组（ P＜0．01）；在口服耐受性方面，聚乙二醇组不如磷酸钠盐组好（ P＜0．01）；而在肠道清洁有效性方面两组差异无统计学意义（ P ＞0．05）。结论聚乙二醇与磷酸钠盐作为口服泻剂，有其各自的优势与劣势，临床工作中可根据患者各自的特点，选择适宜的泻剂。%Objective To evaluate the efficacy and safety of polyethylene glycol versus sodium phos-phates for cleaning intestines by meta-analysis.Methods Through searching Embase, PubMed, Cochrane database to collect randomized controlled clinical trials of oral polyethylene glycol and sodium phosphates for cleaning intestines,RevMan 5.2 software provided by Cochrane with a fixed-effect model analysis was used to evaluate 12 studies included.Results Polyethylene glycol had a lower incidence of side effect(P<0.01), but oral tolerance of polyethylene glycol was worse than sodium phosphates(P<0.01),while the cleanliness had no obvious differences(P>0.05).Conclusion As oral laxative,polyethylene glycol and sodium phos-phates both have their own characteristics,in clinical practice,the choice should be made according to the patients′features.