大环内酯类抗生素治疗类风湿关节炎的机制研究进展

摘要

Rheumatic arthritis(RA) is a chronic inflammatory systemic autoimmune disease that is char-acterized by polyarthritis with progressive joint damage ,in which immune system disorder plays an important role.A variety of antirheumatic treatments,including non-steroidal anti-inflammatory drugs,anti-rheumatic drugs,glucocorticoids,biologic agents,which can only reduce the disease activity and induce remission,but not completely control the joint damage.Recently,macrolide antibiotics as an adjuvant therapy in RA,has drawn much attention for its antibacterial activity and immunomodulatory effects ,offering a new option for RA treatment.%类风湿关节炎（ RA）是一种累及多关节且进行性破坏的慢性炎症性系统性自身免疫性疾病，免疫系统的紊乱在疾病的演变中起重要作用。用于治疗 RA的非甾体消炎药、改善病情的抗风湿药、糖皮质激素、生物制剂等均只降低疾病活动度以及诱导缓解，而不能完全控制关节破坏。近年来，大环内酯类抗生素作为辅助治疗，其抗感染和免疫调节作用在 RA中的应用备受关注，为 RA的治疗提供了一种新的手段。