DNA甲基化的相关研究进展

摘要

DNA甲基化是真核生物表观遗传学中一种重要的基因表达调控方式，是一种酶催化的修饰过程。其是在DNA甲基转移酶催化下，将甲基基团转移到胞嘧啶的5位碳原子上，使之转变成5-甲基胞嘧啶的化学修饰过程。在人类和其他哺乳动物中，此修饰过程通常发生在5′-CpG-′二核苷酸的胞嘧啶上。大量相关研究表明，DNA甲基化与人类疾病密切相关。%DNA methylation is an important epigenetic regulation of gene expression in eukaryotes .It is a kind of enzyme catalysis modification process:refers to the chemical modification process of DNA methyl-transferase catalysis,the transfer of methyl groups onto cytosine carbon atom 5, making them into 5-methyl cytosine.In humans and other mammals,the modification process usually occurs in 5'CpG -'dinucleotide cyto-sine.A large number of relevant studies have shown that DNA methylation is closely related to human disea-ses.