Medical Recapitulate

摘要

非酒精性脂肪肝（ NAFLD）是一个总称，其疾病谱包括非酒精性单纯性脂肪肝、非酒精性脂肪性肝炎及其相关的肝硬化与肝癌。 NAFLD 的患病率在持续增加，但其发病机制尚未阐明。近年来，学者们认识到扩张的脂肪组织生成、分泌脂肪因子异常和脂肪组织功能失调与 NAFLD的发展相关。通过回顾近期的数据，该文讨论了引发肝脏三酰甘油积聚的原因、脂肪组织在调节整体脂质代谢平衡中发挥的作用，尤其是肥胖状态下脂肪组织分泌脂联素、瘦素、抵抗素等细胞因子在 NAFLD进展中发挥的作用。%Nonalcoholic fatty liver disease (NAFLD) is an umbrella term,with the disease spectrum ranging from simple steatosis to non-alcoholic steatohepatitis and the related liver cirrhosis and hepatocellular carcinoma.The prevalence of NAFLD continues to increase,but the pathogenesis of NAFLD has not yet been elucidated.In recent years,scholars have recognized that dysregulated production or secretion of these adipo-kines caused by excess adipose tissue and adipose tissue dysfunction contribute to the development of NAFLD.By reviewing the recent data,here is to discuss the cause of accumulation of triglycerides in the liver,the role of adipose tissue in regulating lipid metabolism balance as a whole ,the role of adipose tissue secretion of adipokines such as adiponectin,leptin and resistin and so on for the improvement of NAFLD in the state of obesity.