腹膜透析患者相关炎性因子的研究进展

摘要

腹膜透析患者长期存在的微炎症状态是导致透析失败的重要因素。 C 反应蛋白、白细胞介素、肿瘤坏死因子α、转化生长因子β1、降钙素原等腹膜透析相关炎性因子是微炎症状态的重要调控因素，也是判断患者预后的重要监测指标。研究炎性因子的表达和调控微炎症的机制对明确腹膜透析失败机制、增强改进腹膜透析疗效、判断预后均具有重要意义。%Long-standing micro-inflammation state of peritoneal dialysis ( PD ) patients is an important factor leading to dialysis failure.C-reaction protein,interleukin,tumor necrosis factor-α,transforming growth factor-β1 ,procalcitonin and other PD associated inflammatory factors are major factors in micro-inflammation control and are also major prognostic monitoring indexes .The study on the expression of inflammatory factors and the control mechanisms of micro-inflammation are of great significance for understanding PD failure mechanisms,improving PD efficacy and assessing the prognosis.