胰岛素受体酪氨酸激酶底物是一种组织中广泛分布的胰岛素受体酪氨酸激酶底物，不仅参与外界环境信号转导，还能发挥蛋白脚手架作用，参与细胞膜的变形和肌动蛋白细胞骨架的重构。除了上述功能，近几年来国内外有研究发现Src能调控IRTKS促进肿瘤细胞的迁移，IRTKS也参与了EGFR／ERK通路影响细胞侵袭与细胞增殖，并能通过偶联Mdm2与p53介导p53的泛素化从而影响细胞与调控Tks5与凋亡。研究IRTKS在肿瘤中的具体作用机制将为肿瘤的预防、治疗、预后等方面带来新思路。%Insulin receptor tyrosine kinase substrate(IRTKS),which has widespread tissue distribution, has been demonstrated to be required for the regulation of downstream signaling ,as well as function as a scaf-fold protein involved in plasma membrane deformation and actin cytoskeleton remodeling .In addition to the above features,in recent years the study found that Src can regulate IRTKS and enhance cell migration ,and IRTKS also activates EGFR/ERK signaling pathway and promotes cell proliferation , and regulates Tks5 through coupling with Mdm2 and p53 to medicate p53 ubiquitination.The study of the specific mechanism of IRTKS in cancer will bring new ideas to the prevention,treatment and prognosis of tumor.
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