前炎性细胞因子在抑郁症中的作用

摘要

Excessive expression of preinflammatory cytokines such as interleukin-1 and interleukin-6,interferon-γand tumor necrosis factor-αhas been connected to depletion of serotonin in central nervous system and dysfunction of hypothala -mus-pituitary-adrenal axis in depressive patients,resulting in death of the neuronal cells and anhedonia;preinflammatory cytokines also have a synergistic effect on damage of central nervous system.Fortunately,antidepressants can reduce the levelof preinflammatory cytokines,and anti-inflammatory therapy can ameliorate depression,new antidepressants combined anti-inflammatory drugs may have an important application in the treatment of depression.%前炎性细胞因子如白细胞介素1、白细胞介素6、γ干扰素和肿瘤坏死因子α等在抑郁症中多表达增加,过度表达的前炎性细胞因子与中枢5-羟色胺损耗、下丘脑-垂体-肾上腺轴的功能失调有关,促进神经细胞死亡,导致快感缺失;前炎性细胞因子间还可协同作用加重损害中枢神经系统.抗抑郁药物可降低前炎性细胞因子水平,抗炎治疗亦可改善抑郁,以抗炎药物为先导化合物的新药在抑郁症的治疗中有重要的应用前景.