At present,peritoneal dialysis has been widely promoted in clinical,and peritoneal dialysis-related perito-neal fibrosis is the most important reason for the withdrawal of peritoneal dialysis in patients with end-stage renal disease, therefore,it is important to study the mechanism of peritoneal dialysis-associated peritoneal fibrosis. The pathogenesis of peritoneal fibrosis involves renin-angiotensin-aldosterone system,abnormal expression of transforming growth factor β, vas-cular endothelial growth factor and connective tissue growth factor,abnormal aggregation of extracellular matrix, peritoneal dialysate high glucose toxicity and epithelial-mesenchymal transition,therefore the effective prevention and treatment can improve the quality of life,increase peritoneal dialysis efficiency and has great clinical significance.%目前腹膜透析已在临床上广泛推广,腹膜透析相关性腹膜纤维化是终末期肾病患者退出腹膜透析最重要的原因,因此研究腹膜透析相关性腹膜纤维化的机制具有重要意义.腹膜纤维化发病机制涉及肾素-血管紧张素-醛固酮系统,转化生长因子β、血管内皮生长因子和结缔组织生长因子异常表达,细胞外基质异常聚集,腹膜透析液的高糖毒性以及上皮间质转化等多个途径,对其有效防治能改善该类患者的生活质量、提高腹膜透析效能具有重要临床意义.
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