Active vitamin D is a hormone precursor with a variety of biological effects , and it plays a role by combining with vitamin D receptor on the target cells .It is an important participant of calcium phosphorus metabolism in the body , which takes part in cell proliferation , differentiation,apoptosis and cell cycle,signal transduction,and immune regulation, and its role in the treatment of infection ,tumor and even rheumatic disease are also recognized and studied gradually .Active vitamin D levels in patients with systemic lupus erythematosus are declined generally ,and low levels of vitamin D are associ-ated with the occurrence ,activity and complications of the disease .Early screening and supplementation of active vitamin D may benefit for the prognosis of patients with SLE .%活性维生素D是一种具有多种生物学效应的激素前体,其与靶细胞上维生素D受体结合发挥作用.它是体内钙磷代谢的重要参与者,并且与细胞周期,包括细胞增殖、分化、凋亡、信号转导和免疫调节关系密切,其在感染、肿瘤甚至风湿病治疗中的作用也逐渐被认识和研究.系统性红斑狼疮患者体内活性维生素D水平普遍下降,低水平的维生素D与疾病的发生、疾病活动度及并发症发生均存在联系.早期筛查及对症补充活性维生素D可能有利于SLE患者疾病的预后恢复.
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