带状疱疹后神经痛与炎性因子的相关性

摘要

Postherpetic neuraigia(PHN)is a chronic pain syndrome. The occurrence and development of PHN is asso-ciated with infection and immune,involving immune cells,nerve cells and the activation of inflammatory mediator. Studies have shown that inflammatory factors have a close relationship with the disease. By comparing the levels of inflammatory fac-tors in patients with PHN and normal human body,the study is to explore the correlation between inflammatory factors and PHN,which can help the selective treatment of PHN. A variety of inflammatory factors are associated with astrocyte func-tion,which plays an important role in the pain of nerve injury,therefore the deepening study of glial cells,will be helpful to understand the pathogenesis of PHN and eventually cure the disease.%带状疱疹后神经痛(PHN)是一种顽固性慢性疼痛综合征,其发生、发展与机体的感染、免疫等有关,涉及大量免疫细胞、神经细胞及炎性介质的激活,而炎性因子与该疾病有密切联系.当前研究主要是通过比较PHN患者与正常人体内炎性因子水平,探究单一炎性因子与PHN的相关性,以助于有选择性地治疗PHN.多种炎性因子与星形胶质细胞的功能相关,且星形胶质细胞对神经损伤疼痛有重要作用,因此不断深化神经胶质细胞的研究,必将有益于了解PHN的发病机制并最终治愈该疾病.