宫内感染诊断在新生儿缺氧缺血性脑病中的意义

摘要

目的 探讨宫内感染诊断在新生儿缺氧缺血性脑病(HIE)中的意义.方法 选取2011年6月至2014年6月在邯郸市中心医院出生的新生儿711例为研究对象,其中361例宫内感染者作为感染组,另350例无宫内感染者作为非感染组,比较两组患儿性别、胎心异常、胎龄、出生体质量、出生后5 min Apgar评分、有无缺氧病史以及HIE发生情况及程度等情况.结果 感染组新生儿的胎龄、出生体质量、出生后5 min Apgar评分均低于非感染组[(36.5±3.4)周比(38.5±2.9)周、(2.5±0.8) kg比(2.9±0.7)kg、(9.1±1.1)分比(9.7±0.8)分](P＜0.01),两组患儿的性别、胎心异常比较,差异无统计学意义(P＞0.05),感染组HIE发生率(17.7％,64/361)高于非感染组(9.7％,34/350)(P ＜0.05).结论 新生儿若发生宫内感染,HIE的发生率及严重程度均会明显升高,对于此部分患儿必须予以重视.%Objective To analyze the clinical significance of intrauterine infection in neonatal hypoxic-ischemic encephalopathy (HIE).Methods A total of 711 newborns born in Handan Central Hospital from Jun.2011 to Jun.2014 were included as objects,and then divided into an infection group(361 cases,with intrauterine infection) and a non-infection group (350 cases,with no intrauterine infection).The gender,fetal heart abnormalities,gestational age,birth weight,Apgar score of 5 min after birth,istory of hypoxia,the occurrence and extent of HIE of the two groups were compared.Results The gestational age,birth weight and the Apgar score of 5 min after birth of the infection group were significantly lower than those of the non-infection group [(36.5 ± 3.4) week vs (38.5 ± 2.9) week,(2.5 ± 0.8) kg vs (2.9 ± 0.7) kg,(9.1 ± 1.1) score vs (9.7 ± 0.8) score] (P ＜ 0.01).There was no significant difference between the two groups in gender and fetal heart abnormality (P ＞ 0.05).The incidence of HIE of the infection group was higher than that of the non-infection group[17.73％ (64/361) vs 9.7％ (34/350)] (P ＜0.05).Conclusion For the newborns with intrauterine infection in perinatal period,the incidence and severe degree of HIE will significantly increase,so due attention must be paid to such newborns.