神经母细胞瘤中N-myc的作用机制研究进展

摘要

神经母细胞瘤(NB)是儿童期最常见的颅外实体肿瘤,来源于交感神经系统.MYCN基因扩增是目前公认的NB不良预后的标志,该基因在约20%的NB患者中发生扩增或过表达.MYCN基因编码的转录因子N-myc通过调控NB细胞中p53、S期相关蛋白激酶2、鸟氨酸脱羧酶1、双微体2等多种分子的表达以及非编码RNA,调节细胞周期、分化以及凋亡等,进而促进NB演进.对N-myc作用机制的研究将有助于开发治疗NB的新药,以期给患者的治疗带来希望.%Neuroblastoma ( NB) is the most common extracranial solid tumor of young children , arising from the embry-onic sympathetic system .Amplification or over-expression of MYCN gene occurs in 20%NB tissues and predicts poor prog-nosis of NB patients.MYCN gene codes N-myc, which regulates cell cycle ,differentiation and apoptosis by regulating mole-cule expression like p53,S-phase associated kinase 2, ornithine decarboxylase 1, murine double minute 2 and non-coding RNA,and promotes NB development .Studying the mechanism of action is helpful to the development of new drugs for NB treatment and will bring hope to the patients .