Runx2是一种公认的转录因子,对骨髓间充质干细胞向成骨细胞转化的过程起重要作用.体内外的研究表明,它可通过骨形态发生蛋白/Smads、丝裂原活化蛋白激酶信号通路等多种信号转导途径参与骨代谢,心血管系统的异位钙化,牙齿异常发育,肿瘤和器官纤维化等疾病的发生.另外,相关微RNA、环境因素、细胞因子、激素以及中医药提取物等对Runx2所致疾病也具有重要的调控作用.目前其在疾病的发生、发展以及预后的具体作用机制尚未完全明确,以Runx2为靶点治疗临床疾病或将成为研究热点.%Runx2 is an acknowledged transcription factor essential for osteoblast development from mesenchymal stem cells and maturation into osteocytes.Studies in vitro and in vivo have reported that Runx 2 could participate bone metabo-lism,ectopic calcification of cardiovascular system ,abnormal development of teeth ,tumorigenesis,and organ fibrosis through multiple integrated complex pathways,such as bone morphogenetic protein/Smads,mitogen-activated protein kinases and others.Besides,some factors like microRNA,environment,cytokines,hormones and traditional Chinese medicine extract also play a major role in the regulation of the disease induced by Runx 2.However,the function of Runx2 is not completely under-stood in the occurrence ,development and prognosis of the diseases ,and the targeting of Runx2 to treat the diseases may become a hotspot in the field.
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