宫颈病变与阴道上皮内瘤变相关性及高危因素分析

摘要

Vaginal intraepithelial neoplasia ( VAIN ) occurs in the vagina ,which is due to the epithelial lesions caused by atypical hyperplasia .There are still no clear conclusions about the high risk factors ,while with the progress of the study , it′s found that there is a certain correlation between VAIN and cervical disease ,especially that in the presence of cervical intraepithelial neoplasia and cervical cancer ,the patients are often accompanied by VAIN .There has been a breakthrough about the causes of cervical lesions ,that human papillomavirus ( especially high-risk type human papillomavirus infection/persistent infection ) in cervical intraepithelial lesions is the main pathogenic factor , moreover ,sexually transmitted diseases (condyloma acuminatum), smoking can be regarded as the co-factors.With the same histogenesis of vagina and cervix ,high risk factors for cervical lesions may also lead to VAIN ,which may be associated with cervical disease itself ,or the treatment of cervical lesions .%阴道上皮内瘤变(VAIN)是发生于阴道,由于上皮发生不典型增生引起的病变.其高危因素仍没有明确的规定,随着研究的进展发现VAIN与宫颈病变有一定相关性,尤其是宫颈上皮内瘤变和宫颈癌常会伴有VAIN.宫颈病变的致病因素已有所突破:人乳头瘤病毒为宫颈上皮内瘤变的主要致病因子(尤其是高危型人乳头瘤病毒感染/持续感染),性传播疾病(尖锐湿疣)、吸烟等为协同因素.阴道与宫颈有相同的组织学来源,宫颈病变的高危因素可能也会导致VAIN的发生,可能与宫颈病变自身相关,也可能与宫颈病变的治疗有关.