METHODS FOR CHARACTERIZING HUMAN PAPILLOMAVIRUS ASSOCIATED CERVICAL LESIONS

摘要

Methods of monitoring a cervical HPV infection and/or an HPV induced cervical lesion in a subject are provided. Methods of identifying a subject with a cervical HPV infection and/or an HPV induced cervical lesion, with an increased risk of developing cervical squamous cell carcinoma are also provided. The methods comprise performing a genotyping assay on a nucleic acid sample of the subject to determine whether the A3 genotype of the subject comprises at least one copy of an A3A-A3B deletion allele (ΔΑ3Β). In some embodiments, if the A3 genotype of the subject comprises at least one copy of an A3A- A3B deletion allele (ΔΑ3Β) then the subject is advised to receive the next Pap test at a shorter time interval than if the A3 genotype of the subject does not comprise at least one copy of a A3A-A3B deletion allele (ΔΑ3Β). In some embodiments, the subject is diagnosed as having an increased risk of developing cervical squamous cell carcinoma if the A3 genotype of the subject comprises at least one copy of an A3 A- A3 B deletion allele (ΔΑ3Β).