免疫性血小板减少症(ITP)是世界范围内常见的血液系统疾病,主要表现为外周血血小板计数减少,骨髓巨核细胞成熟障碍和临床出血症状.从治疗的远期疗效来看,大部分患者还不能获得持续缓解.目前导致ITP发生的主要机制尚未完全阐明,除抗体介导的血小板破坏以外,多种细胞免疫机制的异常也参与了ITP的发生过程.目前认为自身免疫耐受缺陷引起的自身免疫异常是ITP发生的中心环节.了解ITP的发生机制可为寻找治疗途径,提高治疗效果奠定基础.%Immune thrombocytopenia ( ITP) is a common hematologic disorder worldwide ,with the main performances of peripheral blood platelet count decrease , bone marrow megakaryocyte maturation disorder and hemorrhage .From the per-spective of the long-term curative effect,most of the patients cannot achieve sustained relief .The main mechanism of the occurrence of ITP at present has not yet been fully elucidated:besides antibody-mediated thrombocytopenia ,various abnor-mal cellular immune mechanisms are also involved in the occurrence of ITP .At present ,it is considered that the defects of autoimmune tolerance is the central link of the ITP occurrence .Understanding the occurrence mechanism of ITP can provide basis for seeking the treatment and improving the therapeutic effect .
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