希氏束起搏的研究进展

摘要

Long-term right ventricular apical pacing is known to cause ventricular dyssynchrony,heart failure,persistent atrial fibrillation and increased mortality.His bundle pacing is the most physiological form of ventricular pacing.By maintai-ning conduction through the normal His-Purkinje system,His bundle pacing maintains and restores synchronous electrical activation of both ventricles,and may reduce heart failure.There have been multiple reports on permanent His bundle pacing,which have demonstrated that it is feasible and safe,and can correct bundle branch block,thus protects and improves cardiac function in heart failure patients.It may become the preferred method of cardiac pacing,and may replace the current commonly used biventricular pacing as cardiac resynchronization therapy.%长期右心室心尖部起搏可导致心室收缩不同步、心力衰竭、持续性心房颤动和病死率增加.希氏束起搏是最具生理的心室起搏方式,通过正常的希氏束-浦肯野系统传导,可以保持或恢复双心室同步激动,避免心室收缩的不同步,减少心力衰竭的发生.多个关于永久希氏束起搏的研究表明希氏束起搏是可行和安全的,并能够纠正束支传导阻滞,保护和改善心力衰竭患者的心功能.希氏束起搏可能成为心脏起搏的优选方式,并可能代替目前常用的双心室起搏心脏再同步化治疗方式.