小耳畸形与脊柱侧凸的病因学相关性研究进展

摘要

临床上可以发现小耳畸形患者脊柱侧弯的发生率明显较正常人群高.小耳畸形是一种表现多样的先天性畸形,脊柱侧凸的分类及病因也很复杂,有先天性、特发性、非结构性等.但除Goldenhar等综合征外,具体对于合并何种脊柱畸形、其发生机制如何知之甚少.在遗传学、胚胎发育学以及细胞通路上,两者发病原因之间的关系研究甚少.目前发现,耳再造患者切取肋软骨后可能会发生脊柱侧凸,以及患儿因小耳畸形产生的不健康心理会促进非结构性脊柱侧凸的发生发展.%In clinical practice,it can be observed that the scoliosis morbidity of patients with microtia is remarkably higher than the general population.Microtia is a kind of congenital deformity,and the classification and pathogenesis of scoliosis are complex.Scoliosis consists of types like idiopathic,congenital,nonstructural and so on.However, besides Goldenhar and very few kinds of syndrome,there is no further research explaining the types of correlated scoliosis and its mechanism.Little evidence shows the etiological correlation of them in genetics,embryonic development and signal path.It has been found that the costal cartilage harvesting and unhealthy psychologic problem of microtia patients may lead to scoliosis.