右美托咪定对恶性梗阻性黄疸患者围术期肾功能影响的研究进展

摘要

Dexmedetomidine protects renal function to a certain degree by inhibiting the stress response,stabilizing hemodynamics,and dilating renal vessels.In clinical, patients with malignant obstructive jaundice often have different degrees of renal injury,while surgery and anesthesia can worsen the kidney function and even cause kidney failure.Renal impairment is an important reason for postoperative death of patients with malignant obstructive jaundice.Dexmedetomidine can protect the renal function of patients with malignant obstructive jaundice by different methods.Due to the advantages of dexmedetomidine in renal function protection,it has extensive research and development prospect.%右美托咪定通过抑制应激反应、稳定血流动力学、扩张肾血管等方式在一定程度上起着保护肾功能的作用.临床上恶性梗阻性黄疸患者常存在不同程度的肾功能损伤,手术和麻醉打击使患者的肾功能进一步恶化,甚至导致肾功能衰竭.肾功能损伤是恶性梗阻性黄疸患者术后死亡的重要原因,右美托咪定可通过不同方式保护恶性梗阻性黄疸患者的肾功能.由于右美托咪定在肾功能保护中具有许多优势,故右美托咪定对肾功能的保护具有广阔的研究和开发前景.