胃癌相关基因的研究进展

摘要

胃癌的发生和发展是一种多基因、多步骤的过程,只有研究这些基因的变化,并了解其在细胞分化发育过程中所起到的作用,方能从分子水平角度来进一步阐明胃癌的发生和发展过程,在充分了解其发展的基础上才能研发出具有针对性的药物和治疗方案.通过基因层面的研究发现,松弛素家族受体2基因可为临床胃癌高危人群的筛选、早期诊断、病情考核奠定实验室基础;抑癌基因DAB2相互作用蛋白在机体中可能是一种抑癌基因;国内研究人员也首次发现S100A3是胃癌相关基因.其他分子标志物,如FAT4基因、长链非编码RNA-p21等也与胃癌的发生和发展密切相关.除此之外,既往关注较少的如锌指蛋白ZMYM5基因、EPB41基因等在近年来也被发现与多种肿瘤相关,未来可能是研究重点.%The occurrence and development of gastric cancer is a multi-gene and multi-step process,and studies on the changes in cancer related genes in the development,understanding the specific roles of these genes in the process of cell dif-ferentiation and development,are necessary to clarify the mechanism of gastric cancer and metastasis on the molecular level, so as to develop targeted drugs and treatment programs.Through the research on the gene level,it′s discovered that RXFP2 gene can set up the laboratory basis for high risk population screening,early diagnosis and condition assessment for clinical gastric cancer;DAB2IP may be a tumor suppressor gene in the body;domestic researchers discovered for the first time that S100A3 is also a gastric cancer related gene.Other molecular markers,such as FAT4 gene,lincRNA-p21 are also closely related to the occurrence and development of gastric cancer.In addition,previously less concerned genes such as zinc finger protein ZMYM5 gene and EPB41 gene have also been found associated with many kinds of tumors,which might by the focus of the study in the future.