Objective To investigate effects and safety of triple therapy on the basis of Xiyanping Injection in treatment of children with pneumonic antibiotic associated diarrhea.Methods A total of 150 children with pneumonic antibiotic associated diarrhea during July 2014 and July 2015 were divided into control group (n =75) and treatment group (n =75) according to treatment methods.Control group was treated with pidotimod combined with bifid triple viable organism,while treatment group was treated with Xiyanping injection on the basis of treatment for control group.Shoat-term effect,defecation frequency,the recovery time of character,white blood cell count (WBC) levels,fecal ball/ bacillus ratio,stool secreted immunoglobulin (sIgA) levels,blood immunoglobulin a (IgA) and IgM and T-lymphocyte subsets levels before and after treatment and incidence rate of adverse effects were compared in two groups.Results In observation group,the total effective rate was significantly higher than that in control group (P ＜ 0.05),and values of defecation frequency and recovery time of character were significantly lower than those in control group (P ＜ 0.05).After treatment,values of WBC,fecal ball/bacillus ratio and CD8 + level were significantly lower than those before treatment in two groups (P ＜ 0.05),and the values of above indexes in observation group were significantly lower than those in control group (P ＜ 0.05);the IgA,IgM,CD3 +,CD4 +,CD4 +/CD8 + and fecal sIgA values were significantly high er than those before treatment in two groups (P ＜ 0.05),and the values in observation group were significantly higher than those in control group (P ＜ 0.05).Conclusion Triple therapy on the basis of Xiyanping Injection in treatment of children with pneumonic antibiotic associated diarrhea can efficiently improve clinical symptoms and signs,shorten course of disease and improve immunity function without increasing incidence of adverse effects.%目的 探讨以喜炎平为主三联方案治疗小儿肺炎抗生素相关性腹泻的效果及安全性.方法 研究对象选取解放军105医院2014年7月-2016年7月收治小儿肺炎抗生素相关性腹泻患儿共150例,按照治疗方法不同分为对照组(75例)和观察组(75例),对照组给予匹多莫德+双歧杆菌三联活菌,观察组在对照组基础上加用喜炎平,比较两组的近期疗效、大便次数与性状恢复正常时间,治疗前后白细胞计数水平、粪便球/杆菌比例、粪便sIgA水平、血IgA和IgM、T淋巴细胞亚群水平及不良反应发生情况等.结果 观察组总有效率高于对照组(P＜0.05),大便次数与性状恢复正常时间均显著短于对照组(P＜0.05).治疗后,两组白细胞计数、粪便球/杆菌比例及CD8+水平低于治疗前(P＜0.05),观察组低于对照组(P＜0.05);两组IgA、IgM、CD3+、CD4+、CD4 +/CD8+和粪便sIgA高于治疗前(P＜0.05),观察组高于对照组(P＜0.05).结论 以喜炎平为主三联方案治疗小儿肺炎抗生素相关性腹泻可有效改善症状体征,缩短病程,提高机体免疫功能,且未增加不良反应发生风险.
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