新生儿败血症血清降钙素原的动态改变

摘要

目的：分析新生儿败血症患儿血中降钙素原(procalcitonin PCT)的动态改变。方法：采用免疫荧光定量法检测10例新生儿败血症患儿血中 PCT及10例缺血缺氧性脑病(HIE)的动态改变，同时以10例正常足月儿作为正常对照进行分析。结果：新生儿败血症患儿在急性期 PCT与正常对照组比较，数值明显升高，两者比较有统计学意义[(109.13±10.23)μg/L vs (6.87±1.12)μg/L],(P<0.01)；经用抗生素治疗1周后降至正常范围(9.08±2.18)μg/L vs (8.15±2.65)μg/L，(P>0.05)；而 HIE组患儿 PCT与正常对照组两者比较无明显的差异。结论：通过针对 PCT的检测，本研究者认为该方法操作方便，特定性强，可作为新生儿细菌感染检测的早期诊断的标志物，值得临床推广应用。%Objective:To study the changes of serum procalcitonin(PCT) in neonates with sepsis. Methods:Serum PCT was determined using an immunorado metric assay in 10 newborn infants with neonatal sepsis,10 neonates with hypoxic-ischemic encephalopathy (HIE) and 10 healthy newborn controls.Results:Increased levels of serum PCT were found in neonates with sepsis compared with the control group [(110.12±11.12)μg/L vs(7.66±1.13)μg/L],(P<0.01). After 1 week of t reatment with appropriate antibiotics,PCT levels returned to normal(9.12±3.13)μg/L vs (7.65±2.67)μg/L,(P>0.05). There was no difference between HIE neonates and the control group.Conclusions:Elevated serum PCT levels are noted in neonatal sepsis. PCT might be of value in the diagnosis of neonatal sepsis.