尿α1-MG联合血清Cys-C检测在2型糖尿病肾损害早期诊断中的价值

摘要

Objective: To explore the clinical value of urine microglobulin, alpha (α1- MG) combined with serum Cystatin C (Cys- C) testing in the early diagnosis of renal damage in patients with type 2 diabetes mellitus (T2DM) . Methods:According to 24h urinary albumin excretion rate (UAER) level of 56 patients with simple DM (simple DM group) and 54 patients with early diabetic nephropathy(early DN group) and 50 cases of healthy physical examination(normal group) as the research object, Results retrospective analysis urinary α1- MG and serum Cys- C, serum creatinine (SCr) and serum urea (SUrea) were retrospectively analyzed on the MINDRAY BS800 automatic biochemical analyzer. Results: The levels of urinary α1- MG and serum Cys- C in DM group and early DN group were significantly higher than those in the normal group, the difference was statistically significant or highly significant ( <0.05 or <0.01). The levels of urinary α1- MG and serum Cys- C in the early DN group were significantly higher than those in the simple DM group, and the difference was statistically significant ( <0.01);The levels of SCr and SUrea were increased in different degrees, but the difference was not statistically significant ( >0.05);In the early DN group, the positive testing rate of urinaryα1- MG and serum Cys- C was 81.48%, Compared with the simple DM combined testing and the positive testing rate of individual indicators in each group, the difference was statistically significant ( <0.05). Conclusion: Urinary α1- MG and serum Cys- C are sensitive indicators of early diagnosis of diabetic renal function damage. In the early diagnosis and treatment of renal damage in T2DM, the changes should be closely watched. joint testing can improve the testing rate of early renal damage in T2DM, In order to provide a timely and accurate diagnosis, treatment and prevention of complications of laboratory based on T2DM.%目的：探讨尿α1-微球蛋白（α1- MG）联合血清胱抑素 C （Cys- C）检测在2型糖尿病（T2DM）肾损害早期诊断中的临床价值。方法：根据24h尿微量白蛋白排泄率（UAER）水平选择56例单纯DM患者（单纯DM组）和54例早期糖尿病肾病患者（早期DN组）与50例同期健康体检者（正常组）作为研究对象，对在迈瑞BS800全自动生化分析仪上检测尿α1- MG和血清Cys- C、血清肌酐（SCr）、血清尿素（SUrea）的结果回顾性分析。结果：单纯DM组和早期DN组检测尿α1- MG和血清Cys- C水平明显高于正常组，比较差异有统计学意义或高度统计学意义（＜0.05或＜0.01）；早期DN组检测尿α1- MG和血清Cys- C水平显著高于单纯DM组，比较差异高度统计学意义（＜0.01）；各组中检测SCr和SUrea水平呈不同程度的升高，但差异无统计学意义（＞0.05）；在早期DN组尿α1- MG和血清Cys- C联合检测阳性检出率为81.48%，与单纯DM联合检测以及各组单项指标阳性检出率比较，差异有统计学意义（＜0.05）。结论：尿α1- MG和血清Cys- C是糖尿病肾功能损害早期诊断的敏感指标，在T2DM肾损害早期诊治过程中应密切关注其变化。联合检测有利于提高T2DM肾损害早期的检出率，为基层医院医生及时、准确地提供T2DM的早期诊断、治疗及预防并发症的实验室依据。