Objective Changes of coagulation system and anti coagulation factors in patients with nephrotic syndrome. Meth-ods During the period from January 2015 to February 2016, 20 patients with nephrotic syndrome in our hospital were randomly selected as study subjects. 20 physical examination person served as control group, APTT, D- dormer, ATIII, and protein C were detected. Results Among 20 patients with nephrotic syndrome APTT showed a tendency to decrease, while D- Dimmer was sig-nificantly increased. The difference was statistically significant ( <0.05) . Protein C activity was significantly lower than that of healthy controls, but a small part is compensatory increased. Antithrombin III (ATIII) was easily filtrated from the lesion of glomerular fil-tration, Reduction of plasma levels of ATIII in patients with nephrotic syndrome significantly increased endogenous coagulation ac-tivity, and cause thrombosis. The difference was statistically significant ( <0.05) . Conclusion The coagulation indexes of patients with nephrotic syndrome were significantly changed compared with healthy controls, In the state of high coagulation and fibrinolysis, a condition of thrombosis. Clinicians should take preventive measures according to the results of the assessment of the corresponding risks in accordance with the changes in time .%目的：对肾病综合征患者凝血及抗凝血系统各因子变化的研究。方法：2015年1月～2016年2月期间，随机选择在我院住院的20例肾病综合征患者作为研究对象。以同期健康体检者20例作为对照组，测定APTT、D- D、抗凝血酶III、蛋白C。结果：20例肾病综合征患者APTT呈缩短趋势, D- D明显升高，差异具有统计学意义(<0.05)，蛋白C活性与健康对照组相比均明显减低,但有少部分出现代偿性升高。抗凝血酶Ⅲ（ATIII）极易从病变的肾小球滤过，ATIII血浆中含量减少促使肾病综合征患者内源性凝血活性大大增高，而引起的血栓形成，差异有统计学意义(<0.05)。结论：肾病综合征患者凝血指标较健康对照有明显变化，处于高凝及纤溶亢进状态，有血栓形成的条件。临床医师应根据结果评估相应风险及时依据指标变化采取预防措施。
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