Objective:To investigate the distribution and drug resistance of pathogenic bacteria in elderly patients with diabetes mellitus, and to provide reliable and scientific basis for clinical treatment.Methods:Collected from our hospital inpatient treatment of elderly diabetic patients with opportunistic infections in patients with totally (January2010-December2011),248specimens,125patho gens were isolated ,using the France bio-Merieux ATB-new production of bacterial identification and susceptibility analysis system and supporting the identification and susceptibility andpanels on the separation of bacteria identification and susceptibility testing. Results: Totally 248 specimens, 125 pathogens were isolated,and the positive rate is 50.4%,The gram negative bacteria accounted for 69.9%, gram positive bacteria accounted for 21.6%, fungi accounted for 8.8%. The detection rate of major pathogens in descending order: Escherichia coli,Pseudomonas aeruginosa, pneumonia grams Klebsiella pneumoniae,Staphylococcus aureus, Staphylococcus aureus,Candida albicans, and Acinetobacter.Conclusions:Opportunistic infections in elderly patients with opportunistic infections are gram negative bacteria, including Escherichia coli and Pseudomonas aeruginosa are the main infection bacteria, Staphylococcus aureus and fungal infection rate increased gradually. Therefore, clinicians should pay more attention to the monitoring of pathogenic bacteria in elderly patients with diabetes, rational use of antimicrobial agents, control the incidence of opportunistic infections, and reduce the occurrence of drug resistant strains.%目的：探讨老年糖尿病机会感染患者病原菌的分布及耐药性，为临床提供可靠而科学的治疗依据。方法：收集我院2010年1月至2011年12月住院治疗的老年糖尿病合并机会感染患者的送检标本，248份标本中，共分离出125株病原菌，采用法国生物-梅里埃公司生产的ATB-new细菌鉴定及药敏分析系统及配套的鉴定和药敏板对分离的细菌进行鉴定及药敏试验。结果：送检标本248份，共检出125株病原菌，阳性率为50.4%，其中革兰氏阴性菌占69.6%，革兰氏阳性菌占21.6%，真菌占8.8%。主要致病菌检出率从高到低依次为：大肠埃希菌、铜绿假单胞菌、肺炎克雷伯菌、表皮葡萄球菌、金黄色葡萄球菌、白色念珠菌、和不动杆菌。结论：老年糖尿病机会感染致病菌多为革兰氏阴性菌，其中大肠埃希菌和铜绿假单胞菌是主要感染菌群，表皮葡萄球菌和真菌感染率逐渐增高。因此，临床医生要重视老年糖尿病机会感染病原菌的监测，合理使用抗菌药物，控制机会感染的发生率，减少耐药菌株的发生。
展开▼
