过敏性紫癜患儿外周血IL-16、IL-18水平的研究

摘要

目的 探讨IL-16、IL-18在过敏性紫癜患儿中的应用价值.方法 采用固相酶联免疫分析法检测69例过敏性紫癜患儿血清IL-16、IL-18水平.结果 过敏性紫癜急性期患儿血清IL.16、IL-18较健康对照组明显升高(P＜0.01),而过敏性紫癜缓解期患儿与健康对照组间无显著差异(P＞0.05).过敏性紫癜患儿IL-16与IL-18呈正相关.结论 IL-16、IL-18可能参与过敏性紫癜血管炎的发病,IL-16、IL-18的检测与过敏性紫癜病情发展有一定关系.%Objective To investigate the clinical significance of IL-16 and IL-18 in Henoch -schonein purpur (HSP) children. Methods An enzyme-linked immunosorbent assay(ELISA)was utilized to detect the levels of IL-16 and IL-18 in serum of 69 children with HSP. Results Statistical analysis showed that the serum levels of IL-16 and IL-18 in HSP were significantly higher than those of healthy control respectively(P＜0. 01), while there was no significance between recessive HSP and healthy control(P＞0.05). The levels of IL-16 were correlated with IL-16. Conclusion IL-16 and 1L18 might play an important role in the pathogenesis of HSP,and they are associated with the disease activity of HSP.