Objective To analyze the content of clinical significance of urinary cytomegalovirus DNA (HVMV-DNA )in type 2 diabetic patients with nephropathy before and after treatment. Methods 52 cases of type 2 diabetic patients with nephropathy were selected as the observation group, and 52 healthy adult subjects as the control group. The observation group patients were divided into different subgroups according to renal function, and the HCMV-DNA levels in urinary of patients were compared before and after treatment. Results The HCMV positive cases of observation group patients before treatment were 4 cases, were higher than that of control group (0 cases). The difference was statistically significant (P<0. 05). The positive rate of urinary HCMV in mild renal insufficiency patients after treatment was 3.70%,moderate renal insufficiency was 37. 50%, severe renal insufficiency was 44. 44%, different groups had significant difference (P<0. 05). Conclusion Type 2 diabetic nephropathy patients prone to HCMV infection, in addition to its resistance to treatment and immunosuppressive agents on the outside, but also related to severity of illness in patients.%目的 分析Ⅱ型糖尿病肾病患者治疗前后尿巨细胞病毒DNA(HVMV-DNA)含量及其临床意义.方法 选取进行治疗的Ⅱ型糖尿病肾病患者52例作为观察组,同时选取在门诊进行健康体检的健康成人52例作为对照组,依据观察组患者的肾功能对其进行分组,并比较患者治疗前后尿HCMV-DNA含量水平.结果 观察组患者治疗前的HCMV阳性例数为5例,高于对照组的0例,差异有统计学意义(P＜0.05)；治疗后轻度肾功能不全患者的尿HCMV阳性率为3.70％,中度肾功能不全为37.50％,重度肾功能不全为44.44％,不同组别比较差异有统计学意义(P＜0.05).结论 Ⅱ型糖尿病肾病患者容易发生HCMV感染,除了和自身抵抗力及免疫抑制剂治疗有关外,还与患者自身病情严重程度有关.
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