探讨建立伽玛刀损伤恒河猴视神经动物模型立体定位头架的操作技术

摘要

目的 探讨建立伽玛刀损伤恒河猴视神经动物模型立体定位头架的可行性和适合方法.方法 对2009年8月～2010年10月选择的11只恒河猴,全麻下使用Leksell(Θ) Coordinate Frame model G型系列头架行立体定位头架佩带操作,通过MRI及CT定位扫描并完成最终治疗.分析操作过程头架稳固程度和速度,找到最适合的操作方法和最适合恒河猴的头架类型.结果 均采用Slotted Front Piece框架基环及双Insulated Fixation Posts,Short Posterior 的三点定位,前支使用Fixation Posts Anterior者5只,有1只有头架滑落,前支使用Insulated Curved Posts kit者6只,都顺利完成伽玛刀照射全过程.结论 选用Slotted Front Piece框架基环及双Insulated Fixation Posts,Short Posterior 后支杆和Insulated Curved Posts kit前支杆能快速成功完成操作,且具有良好的可操作性和稳固性.%Objective To investigate the possibilities and suitable methods of wear stereotactic frame for rhesus monkeys to establish a traumatic optic rhesus model by gamma knife. Methods 11 rhesus monkeys were installed with stereotactic frame Leksell coordinate frame model G after general anesthesia. Among the 11 cases installed with stereotactic frame Leksell coordinate frame model G, the slotted front piece base ring, double insulated fixation posts, short posterior post branch, were divided into: 1 group with fixation posts, anterior anterior branch and 2 group with insulated curved posts kit anterior branches. The operation speed and frame stability were analyzed to find the best method and the suitable frame for rhesus. Results 1 failed in 1 group, and the group taken more time. All succeed in 2 group with less time. Conclusion Choice stereotactic frame Leksell coordinate frame model G, the slotted front piece base ring, double insulated fixation posts, short posterior post branch, insulated curved posts kit anterior branches made establish a traumatic optic rhesus model by gamma knife treatment easily and successfully.