胸腔局部顺铂联合热灌注治疗恶性胸腔积液疗效观察

摘要

目的 探讨胸腔局部顺铂联合热灌注治疗恶性胸腔积液的临床疗效.方法 将出现恶性胸腔积液的非小细胞肺癌患者76例随机均分为顺铂治疗组和热灌注十顺铂治疗组,两组患者均给予顺铂局部治疗,热灌注十顺铂治疗组患者在顺铂局部治疗的基础上给予胸腔热灌注辅助治疗.治疗两个疗程后,对两组患者进行临床疗效评定和生存质量评分测定.结果 在通过两个疗程的治疗后,临床疗效观察显示,顺铂治疗组有效率为42.1％；热灌注十顺铂治疗组有效率为78.9％.两组间临床疗效的差异有统计学意义(x2=17.113,P=0.001).生活质量评分显示,顺铂治疗组改善率为34.2％,热灌注十顺铂治疗组改善率为63.2％,两组间有效率差异有统计学意义(x2=10.868,P=0.004).结论 胸腔热灌注辅助治疗恶性胸腔积液安全有效,可在临床推广应用.%Objective To investigate the effect of intrapleural hyperthermic perfusion (CIHP) on the management of malignant pleural effusion (MPE). Methods Seventy six patients with non-small cell lung cancer (NSCLC) induced malignant pleural effusion (MPE) were randomly separated into 2 groups (n=38) , cisplatin group and CIHP+ cisplatin group. After 2 courses of treatment, response rates and KPS scores were observed. Results After 2 courses of treatment, response rates and KPS scores in CIHP+ cisplatin group were better than in cisplatin group. No severe side effect was found in the CIHP treatment. Conclusion Intrapleural hyperthermic perfusion (CIHP) is a safety and effective treatment on malignant pleural effusion.