缬沙坦联合黄葵胶囊对高血压合并Ⅱ型糖尿病肾病患者血压血糖水平和肾脏的影响

摘要

Objective To investigate the effect of valsartan combined with Huangkui capsule on Blood pressure,blood sugar levels and renal function in patients with hypertension complicated with type 2 diabetic nephropathy,to provide reference for clinical treatment.Methods 80 patients with hypertension complicated with type 2 diabetic nephropathy from January 2014 to June 2016 in our hospital were selected.According to the random number table method,the patients were divided into observation group and control group,each of 40 cases.The control group was treated with valsartan.The observation group was treated with valsartan combined with Huangkui capsule.After 8 weeks of treatment,the clinical efficacy and blood pressure,blood glucose,renal function were compared between the two groups.Results After 8 weeks of treatment,the total effective rate of the observation group was significantly higher than that of the control group.The diffcrcncc was statistically significant (P＜0.05).SBP,DBP,MAP,FBS,PBG2h,HbAIc,UAER and 24hPro were all significantly lower in the 2 groups after treatment than before treatment (P＜0.05).SBP,DBP,MAP,FBS,PBG2h,HbAIc,UAER and 24hPro of the observation group was significantly lower than that of the control group.The difference was statistically significant (P＜0.05).There was no significant difference in the incidence of adverse reactions between the 2 groups (P＞0.05).Conclusion The effect of valsartan combined with Huangkui capsule improves blood pressure associated with type 2 diabetic nephropathy treatment effect,improve the blood pressure,blood glucose and renal function,and did not increase the incidence of adverse reactions.%目的 探讨缬沙坦联合黄葵胶囊对高血压合并Ⅱ型糖尿病肾病患者血压、血糖和肾功能的影响,为临床治疗提供参考依据.方法 选取我院2014年1月～2016年6月收治的80例高血压合并Ⅱ型糖尿病肾病患者作为研究对象,根据随机数字表法分为观察组和对照组各40例,对照组给予缬沙坦治疗,观察组给予缬沙坦联合黄葵胶囊治疗,治疗8周后,比较两组患者的临床疗效以及血压、血糖、肾功能变化情况.结果 治疗8周后,观察组总有效率明显高于对照组,组间差异有统计学意义(P＜0.05);两组患者治疗后SBP、DBP、MAP、FBS、PBG2h、HbAIc、UAER、24hPro均明显低于治疗前(P＜0.05);观察组SBP、DBP、MAP、FBS、PBG2h、HbAIc、UAER、24hPro均明显低于对照组,差异有统计学意义(P＜0.05);两组患者不良反应发生率比较,差异无统计学意义(P＞0.05).结论 缬沙坦联合黄葵胶囊提高了高血压合并Ⅱ型糖尿病肾病的治疗效果,改善了患者血压、血糖水平和肾功能,且未增加不良反应的发生率,可在临床推广应用.