Objective To investigate the effect of probiotic combined fructo-oligosaccharid treatment on microflora of neonatal children infected with antibiotic associated diarrhea.Methods 45 children with antibiotic associated diarrhea were divided into microecologic cure group,microecologic+ fructo-oligosaccharid cure group and conventional cure group,15 children in each group.Bifid-triple viable capsule were given to microecologic cure group compared with conventional cure group.Fructo-oligosaccharid were eaten in microecologic+fructo-oligosaccharid cure group compared with microecologic cure group.The time of recovery and population of major bacteria were compared.Results The time of recovery in conventional cure group were significantly higher than that in microecologic cure group and microecologic+fructo-oligosaccharid cure group (P<0.05).The population of bifidobacterium and lactobacillus in microecologic cure group and microecologic+fructo-oligosaccharid cure group were significantly higher than those in conventional cure group (P<0.05).The population of bifidobacterium in microecologic cure group and were significantly lower than that in microecologic+fructo-oligosaccharid cure group (P<0.05).The population of E.Coli in convention cure group were significantly higher than that in microecologic+fructo-oligosaccharid cure group (P<0.05).Conclusion Probiotic preparation combined microecologic+fructo-oligosaccharid treatment can improve population of bifidobacterium and lactobacillus and reduce antibiotic associated diarrhea of children.The effect of microecologic can be enhanced by fructo-oligosaccharid.%目的 探究益生菌制剂治疗对抗生素诱发腹泻儿童肠道菌群的影响.方法 选取45例本院因肺部感染使用抗生素后腹泻的住院儿童,其中15例作为微生态治疗组,15例作为微生态+低聚果糖治疗组,15例作为常规治疗组.微生态治疗组在常规治疗的基础上,同时口服三联双歧杆菌胶囊;微生态+低聚果糖治疗组在微生态治疗组基础上口服低聚果糖;常规治疗组则按症状采用一般常规治疗.比较各组腹泻治愈时间及肠道主要菌群数量.结果 常规治疗组肠道内双歧杆菌和乳酸杆菌数量低于微生态治疗组和微生态+低聚果糖组(P<0.05);腹泻时间长于微生态治疗组和微生态+低聚果糖组(P<0.05);大肠杆菌数高于微生态+低聚果糖组(P<0.05);微生态组肠道内双歧杆菌数量低于微生态+低聚果糖组(P<0.05).结论 益生菌制剂联合低聚果糖治疗可提高抗生素诱发腹泻患儿肠道内双歧杆菌和乳酸菌数量,降低小儿抗生素相关性腹泻治愈时间,低聚果糖可加强益生菌的治疗效果.
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