低分子肝素钠联合红花注射液预防下肢骨折术后深静脉血栓形成的临床效果

摘要

Objective To observe the clinical effect of low-molecular-weight heparin sodium combined with Honghua injection on the prevention of deep venous thrombosis (DVT) after operation of lower limb fracture.Methods 158 patients were randomly divided into control group and observation group.78 cases in control group were treated with lowmolecular-weight heparin for two weeks.80 cases in observation group were treated low-molecular-weight heparin sodium combined with Honghua injection for two weeks.The incidence of DVT,hemorheology and blood coagulation state were measured and compared at two weeks after operation.Results The incidence of DVT in the observation group was lower than that in control group (3.75％ vs 14.10％,P ＜0.05).Plasma viscosity and the whole blood viscosity (low shear and high shear) in the observation group were significantly lower than that in control group (P ＜0.05).The prothrombin time (PT)and activated partial thromboplastin time (APTT) of observation group were significantly higher than control group(P ＜0.05).D-dimer in the observation group was significantly lower than that in control group (P ＜0.05).There were no obvious adverse reactions in the two groups.Conclusion Treatment of low-molecular-eight heparin sodium combined with honghua injection on postoperative patients with lower limb fracture could significantly reduce the incidence of DVT and improve blood hypercoagulable state.%目的 探讨低分子肝素钠联合红花注射液预防下肢骨折术后深静脉血栓形成的临床效果.方法 158例下肢骨折术后患者随机分为观察组和对照组,对照组78例给予低分子肝素钠治疗,观察组80例给予低分子肝素钠和红花注射液治疗,疗程均为14天.观察两组患者深静脉血栓发生率、血液流变学指标和凝血功能变化.结果 观察组深静脉血栓发生率为3.75％,低于对照组的14.10％(P＜0.05);观察组的血浆粘度、全血高切粘度和全血低切粘度指数均明显低于对照组(P＜0.05);观察组的D-二聚体较对照组下降明显(P＜0.05),而PT及APTT较对照组升高(P＜0.05).两组均未见明显不良反应患者.结论 低分子肝素钠联合红花注射液能够降低下肢骨折术后深静脉血栓发生率,改善血液高凝状态.