Ethyl-3-(2-{4-(hexyloxycarbonylamino-imino-methyl)-phenylamino-methyl}-1- methyl-1h-benzimidazol-5-carbonyl)-pyridine-2-yl-amino-propionic acid ethyl ester methane sulphonate in crystalline form ii, pharmaceutical composition comprising it and uses thereof for preparing pharmaceutical compositions which are suitable for the post-operative prophylaxis of deep vein thrombosis and the prevention of stroke and process for the preparation thereof

摘要

Ethyl 3-(N-(2-(4-(hexyloxycarbonylamidino)phenylaminomethyl)-1-methyl-1H-benzimidazole-5-carbonyl)-N-(2-pyridyl)amino)propionate methanesulfonate polymorph I (Ia), polymorph II (Ib) and hemihydrate (Ic), with melting points of 180+-3[deg]C, 190+-3[deg]C and 120+-5[deg]C respectively, are new. Independent claims are also included for the preparation of (Ia)-(Ic). ACTIVITY : Anticoagulant; Cerebroprotective; Vasotropic. No biological data is given. MECHANISM OF ACTION : Thrombin inhibitor.