肝硬化患者肝功能与外周血Aβ水平的相关性研究

摘要

Objective To study the correlation between liver function and serum amyloid β (Aβ) levels in peripheral blood of patients with liver cirrhosis.Methods A total of 48 patients with liver cirrhosis treated in our hospital were selected as the research subjects ("liver cirrhosis group"),and 48 healthy persons with the same age and matched sex were selected to constitute a control group.The levels of Aβ40 and Aβ42 in peripheral blood of patients between the two groups were compared,and the correlation between the indexes of liver function was analyzed.Results The liver function in the liver cirrhosis group was significantly poorer than that in the control group,and the levels Aβ40 and A42 in peripheral blood were significantly higher than those in the control group (P ＜ 0.001).Among the patients with liver cirrhosis,the aspartate aminotransferase (AST),alanine aminotransferase (ALT),aspartate aminotransferase / alanine aminotransferase (AST/ALT),total bilirubin (TBIL) and globulin (GTB) levels were positively correlated with both Aβ40 and Aβ42(P ＜ 0.05),and albumin (ALB) and Albumin/globulin (A/G) were negatively correlated with both Aβ40 and Aβ42(P ＜ 0.01).Conclusion There is a significant correlation between the liver function and the Aβ levels in peripheral blood in patients with liver cirrhosis.Abnormal liver function can lead to the elimination or reduction of Aβ levels,and the protection of liver function may help to eliminate the Aβ levels in peripheral blood.%目的 探讨肝硬化患者肝功能相关指标与外周血淀粉样蛋白β(Aβ)水平的相关性研究.方法 以医院治疗的48例肝硬化患者为研究对象,以同时期年龄、性别相匹配的48例健康体检者为对照组.比较两组外周血Aβ40和Aβ42水平,分析肝功能相关指标与Aβ间的相关性.结果 肝硬化组肝功能明显差于对照组,外周血Aβ40和Aβ42水平均显著高于对照组(P＜0.01).肝硬化患者中,谷草转氨酶(AST)、谷丙转氨酶(ALT)、谷草转氨酶俗丙转氨酶(AST/ALT)、总胆红素(TBIL)及球蛋白(GTB)水平与Aβ40和Aβ42间均呈正相关性(P＜0.05),白蛋白(ALB)和白蛋白/球蛋白(A/G)与外周血Aβ40及Aβ42间呈负相关(P＜0.01).结论 肝硬化患者的肝功能与外周Aβ水平间存在显著相关性,肝功能异常可导致外周Aβ清除减低,保护肝功能可能有助于清除外周血Aβ水平.