双环醇与异甘草酸镁联合治疗肝硬化的疗效及安全性分析

摘要

目的 探讨双环醇与异甘草酸镁联合治疗肝硬化的疗效及安全性.方法 选择医院接诊的120例失代偿期肝硬化患者,随机分为双环醇组、异甘草酸镁组和联合组,每组40例.在常规治疗基础上,双环醇组给予双环醇片口服,异甘草酸镁组给予异甘草酸镁注射液静脉滴注,联合组给予双环醇片+异甘草酸镁注射液治疗.治疗2w后,比较3组治疗前后肝功能和肝纤维化指标的变化以及临床疗效.结果 治疗后,联合组丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)、血清总胆红素(TB)、层粘连蛋白(LN)、透明质酸(HA)明显低于其他两组(P＜0.05),临床治疗总有效率也明显高于其他两组(95.00％ vs67.50％和70.00％)(P＜0.05);治疗过程中,3组不良反应无显著差异(P＞0.05).结论 双环醇联合异甘草酸镁治疗失代偿期肝硬化疗效显著,有助于改善患者肝功能和肝纤维化程度,安全性高,且效果好于单用双环醇或异甘草酸镁.%Objective To explore the efficacy and safety of combined bicyclol and magnesium isoglycyrrhizinate in the treatment of liver cirrhosis.Methods A total of 120 patients who had been suffering from decompensated cirrhosis and admitted to our hospital were selected and randomly divided into a bicyclol group,a magnesium isoglycyrrhizinate group and a combination group (n=40,respectively).On the basis of routine treatment,the bicyclol group took bicyclol tablets orally,the magnesium isoglycyrrhizinate group was treated with magnesium isoglycyrrhizinate through intravenous drip,and the combination group was treated with both bicyclol tablets and magnesium isoglycyrrhizinate injection.Two weeks later,the changes in the indicators of liver function and liver fibrosis as well as clinical efficacy before and after the treatment were compared among the three groups.Results After the treatment,the levels of alanine aminotransferase (ALT),aspartate aminotransferase (AST),serum total bilirubin (TB),laminin (LN) and hyaluronic acid (HA) in the combination group were obviously lower than those in another two groups (P ＜ 0.05),and the total effective rate of clinical treatment was also obviously higher than that in the other two groups (95.00％ vs 67.50％ and 70.00％) (P ＜ 0.05);during the treatment,there were no significant differences in adverse reactions among three groups (P ＞ 0.05).Conclusion The combined bicyclol and magnesium isoglycyrrhizinate has significant effect in the treatment of decompensated cirrhosis and can help safely improve the liver functions and liver fibrosis of patients,with better effect than either bicyclol or magnesium isoglycyrrhizinate when used alone.