埃他卡林片对缺氧性肺动脉高压自由基代谢的影响

摘要

Objective: To explore the effects of Iptkalim on free radicals metabolism in patients with hypoxic pulmonary hypertension (HPH). Methods: A total of 110 cases of HPH who stayed at the altitude of 5000 m above were randomly divided into Iptkalim group (experimental group, n =74) and placebo group (n =36). Contents of SOD, MDA, NO and NOS in blood were detected before and 6 months after treatment. Results: No statistical differences were found in contents of SOD, MDA, NO and NOS between the two groups before the treatment ( P > 0. 05 ). The contents of SOD, NO and NOS increased and the contents of MDA decreased significantly in experimental group 6 months after treatment compared with that in placebo group ( P < 0. 05 ). Conclusion: Oxygen free radicals are implicated in the pathogenesis of HPH. Iptkalim play a protective role through reducing the lipid peroxide reaction.%目的:研究埃他卡林对缺氧性肺动脉高压(HPH)患者自由基代谢的影响.方法:在海拔5000 m以上高原,将110名HPH患者随机分为埃他卡林治疗组(实验组,n=74)和安慰剂对照组(n=36).治疗前、治疗6个月后分别采血检测超氧化物歧化酶(SOD)、丙二醛(MDA)、一氧化氮(NO)及一氧化氮合酶(NOS)的含量.结果:服药前实验组较对照组SOD、MDA、NO、NOS无统计学差异(P＞0.05)；服药6个月后实验组较对照组SOD、NO、NOS增高,MDA降低,差异有统计学意义(P＜0.05).结论:氧自由基参与了HPH的发生发展过程,埃他卡林减轻脂质过氧化反应,是对HPH发挥保护作用的重要机制.