阿米替林联合木丹颗粒及甲钴胺治疗痛性糖尿病周围神经病变的疗效观察

摘要

Objective:To observe the clinical efficacy of amitriptyline combined with mudan granule and mecobalamin in the treatment of painful diabetic peripheral neuropathy(PDPN).Methods:A total of 120 patients with PDPN were randomly divided into the treatment group and the control group.And each group included 60 patients.The control group was given the treatment with mudan granule and mecobalamin for four weeks on the basis of blood glucose control,the treatment group was given the treatment with amitriptyline on the basis of the control group for four weeks.The clinical efficacy after treatment of both groups was observed.Results:The two groups both improved in the TCSS scores(P ＜0.05),pain relief and the conduction velocity of the peroneal nerve were better than those in control group (P＜0.05).Conclusion:Amitriptyline combined with mudan granule and mecobalamin can effectively improve the clinical symptoms of PDPN,relieve pain and increase the conductior-velocity of the peroneal nerve and no obvious adverse reaction occurred.%目的:观察阿米替林联合木丹颗粒及甲钴胺治疗痛性糖尿病周围神经病变(PDPN)患者的临床疗效.方法:将120例PDPN患者随机分为治疗组(n=60)和对照组(n=60).两组均给予正规降糖治疗,对照组给予甲钴胺和木丹颗粒治疗4周,治疗组在对照组治疗的基础上加服阿米替林治疗4周,并于4周后分别观察两组患者治疗前后的临床疗效、疼痛缓解程度及腓总神经传导速度变化.结果:两组治疗后多伦多评分(TCSS)均有改善(P＜0.05),但治疗组优于对照组;两组疼痛均有缓解,但治疗组的缓解有效率高于对照组;两组腓总神经传导速度均较治疗前增加,但治疗组优于对照组(P＜0.05).结论:阿米替林联合木丹颗粒及甲钴胺可有效改善PDPN的临床症状,对神经传导速度及疼痛的改善有良好疗效,且无明显不良反应发生.