木丹颗粒联合甲钴胺治疗痛性糖尿病周围神经病变的临床观察

摘要

Objective:To investigate the efficacy of Mudan Particles combined with mecobalamine in the treatment of painful dia-betic peripheral neuropathy (PDPN).Methods:One hundred patients with PDPN were randomly divided into treatment group (n=50)and the control group (n =50).Based on the basic control of blood glucose,the control group were treated with mecobal-amine;the treatment group were treated with Mudan Particles in addition to the control group.Observe the treatment effect and the peroneal nerve conduction velocity of two groups before and after treatment.Results:TCSS of the two groups improved after treat-ment (P <0.05,but the treatment group improved rather significantly.For pain,the total effective rate of the treatment group (86%)was higher than that of the control group.After treatment,MCV and SCV of common personal nerve of the treatment group were faster than those of the control group(P <0.05).Conclusion:Mudan Particles combined with mecobalamine have a good effect on nerve conduction velocity improvement and pain relief in the treatment of PDPN,and have no significant adverse reaction.%目的：观察木丹颗粒联合甲钴胺片治疗痛性糖尿病周围神经病变（Painful Diabetic Peripheral Neuropathy，PDPN）患者的临床疗效。方法：将100例 PDPN 患者随机分为治疗组50例和对照组50例。在控制血糖基础上，对照组给予甲钴胺治疗4周；治疗组在对照组治疗基础上加服木丹颗粒治疗4周，疗程结束后，观察2组临床疗效及治疗前后腓总神经传导速度（NCV）变化。结果：2组治疗后 TCSS 均有改善（P ＜0.05），但以治疗组改善明显；2组对疼痛均有缓解，但治疗组总有效率为86％，高于对照组；治疗组治疗后，腓总神经运动传导速度及感觉传导速度疗效均优于对照组（P ＜0.05）。结论：木丹颗粒联合甲钴胺辅助治疗 PDPN，对神经传导速度及疼痛的改善有良好作用，且无明显不良反应。