共聚焦激光显微内镜在消化道肿瘤及癌前病变中的应用

摘要

Confocal laser endomicroscopy (CLE) is a novel and advanced endoscopic technique, which can clearly display the structures of the mucosal surface and subsurface during ongoing endoscopy, thereby providing immediate diagnosis of mucosal lesions. CLE can distinguish the physiological change from the pathological in the gastrointestinal mucosa by using a fluorescent contrast agent, which demonstrates its potential in diagnosis of gastrointestinal diseases. A series of studies have shown that CLE has high specificity and sensitivity in diagnosis and distinction of gastrointestinal tumors, especially the early cancer and precancerous lesions. The present paper will focus on advances in researches about CLE in gastrointestinal tumors and precancerous lesions.%共聚焦激光显微内镜(CLE)是一项在常规内镜检查同时能清晰地显示黏膜表面及表面下组织结构,从而对黏膜病变做出即时诊断的全新的内镜技术.CLE在荧光对比剂作用下能够对胃肠道黏膜的病理生理改变进行准确诊断,显示了其用于消化道疾病诊断的潜能.一系列研究表明CLE对消化道肿瘤尤其是早期肿瘤及癌前期病变的诊断及鉴别诊断具有较高的特异性和敏感性,本文就其在消化道肿瘤及癌前病变中的应用进展做一综述.