艾司西酞普兰与西酞普兰治疗广泛性焦虑障碍120例临床对照分析

摘要

Objective:To explore clinical effects of Escitalopram and Citalopram in treatment of generalized anxiety disorder, and provide a reference for future clinical work. Methods:According to different treatment methods, 120 patients with generalized anx-iety disorder were divided into control group and observation group. The cases in control group were treated with Citalopram, while those in observation group were given Escitalopram. The clinical effects and adverse reactions of the two groups were observed after the treatment. Results: There were significant differences in the Hamilton anxiety scale (HAMA) scores at the 2nd, 4th, and 6th week-ends of the treatment between the two groups (P<0. 05). At the 6th weekends of the treatment, the total effective rates of Escitalopram group and Citalopram group were 91. 7% and 80. 0% , respectively; and the difference was significant (P<0. 05). The incidences of the adverse reactions of Escitalopram group were significantly lower than those of Citalopram group, and the difference was statistically significant (P<0. 05). Conclusions: Escitalopram in the treatment of generalized anxiety disorder has good clinical effects, less ad-verse reactions, and is safe and effective. Therefore, it is worthy of promotion.%目的：探究艾司西酞普兰与西酞普兰治疗广泛性焦虑障碍的临床效果，为今后的临床工作提供参考依据。方法：选取广泛性焦虑障碍患者120例，按照治疗方法的不同分为对照组与观察组，对照组患者给予西酞普兰治疗，观察组患者给予艾司西酞普兰治疗，观察两组患者治疗后的临床效果及不良反应。结果：治疗第2、4、6周末，两组患者 HAMA 比较差异显著(P<0.01)；治疗6周末，艾司西酞普兰组的总有效率为91.7%，西酞普兰组的总有效率为80.0%，比较差异有统计学意义(P<0.05)。艾司西酞普兰组患者的不良反应明显低于西酞普兰组(P<0.05)，差异有统计学意义。结论：艾司西酞普兰治疗广泛性焦虑障碍临床效果良好，不良反应少，值得临床推广使用。