文拉法辛缓释片对首发抑郁症患者事件相关电位 P300的影响

摘要

Objective:To study effects of venlafaxine extended release tablets on event-related potential P300 in first episode depression patients. Methods:32 patients with first-episode depression were enrolled as research group and treated with venlafaxine extended release tablets. 24-item Hamilton rating scale for depression (HAMD-24) and P300 were used to evaluate the effects of drugs and cognitive function before and 6 weeks after the treatment. 30 healthy individuals were selected as normal control group with the matched sex and age. Results: After 6 weeks' treatment, the scores of HAMD-24 of research group decreased significantly, and the differences were statistically significant before and after the treatment (P<0. 05). Before the treatment, the amplitude and the la-tency of P300 were reduced and prolonged in research group compared with those of normal control group, and the differences were sta-tistically significant (P<0. 05). After the treatment, the amplitude and the latency of P300 increased and were reduced compared with those before the treatment in research group, and the differences were statistically significant (P<0. 05). Conclusions: The patients with depression have cognition deficits. Venlafaxine extended release tablets have therapeutic efficacy and can improve the cognitive function for the depression patients.%目的：探讨抗抑郁药文拉法辛缓释片对首发抑郁症患者P300认知电位的影响。方法：共收集32例使用抗抑郁药文拉法辛缓释片的首发抑郁症患者作为研究组，在治疗前及治疗6周后，用24项汉密尔顿抑郁量表( HAMD-24)判定其疗效，进行事件相关电位P300测定判定其认知功能，并选30例与研究组性别、年龄相匹配的健康人作为对照组进行对照研究。结果：治疗6周后，首发抑郁症患者24项汉密尔顿抑郁量表总分明显下降，与治疗前相比，差异有统计学意义(P<0.05)。 P300认知电位测定显示在治疗前，文拉法辛缓释片治疗组与对照组相比较P300认知电位潜伏期延长，波幅降低，差异具有统计学意义(P<0.05)；治疗后，文拉法辛缓释片治疗组P300认知电位潜伏期缩短，波幅增高，与治疗前相比较差异具有统计学意义(P<0.05)。结论：抑郁症患者存在认知障碍，文拉法辛缓释片对抑郁症具有一定的疗效，且对抑郁症患者的认知障碍具有一定的改善作用。