利培酮和氯丙嗪对慢性精神分裂症患者认知功能影响的对照研究

摘要

目的：：探讨利培酮对慢性精神分裂症患者认知功能的影响。方法：将符合入组标准的精神分裂症60例患者随机分为利培酮组和氯丙嗪组，每组30例。两组患者分别进行12周系统治疗，用阳性与阴性症状量表(PANSS)、修订韦氏记忆量表(WMS-RC)、中国成人智力量表( CISA)进行检查与评估，比较两组患者疗效和对认知功能的影响。结果：利培酮组患者的PANSS总分、阴性症状和一般病理性症状因子分均显著低于氯丙嗪组，两组患者之间差异有显著性(P<0.05)，利培酮组患者的认知功能(包括认知总分、心智、再认、背数、图形识别)优于氯丙嗪组，两组患者存在显著差异(P<0.05)。结论：利培酮对慢性精神分裂症患者认知功能和阴性症状的疗效优于氯丙嗪疗效。%Objective:To study effects of Risperidone on cognitive function in patients with chronic schizophrenia. Methods:60 patients with schizophrenia were randomly divided into Risperidone group ( n=30 ) and Chlorpromazine group ( n=30 ) , and were treated for 12 weeks. The therapeutic response and cognitive function of the two groups were assessed by positive and negative symptom scale ( PANSS) , Wechsler adult memory scale ( WMS-RC) , and Chinese adult intelligence scale ( CISA) and compared. Results:The total score of PANSS, and the factor scores of negative symptoms and general pathological symptoms of Risperidone group were sig-nificantly lower than those of Chlorpromazine group, and the differences between the two groups were significant (P<0. 05). The scores of WMS-RC and CISA ( including total score of cognitive function, intelligence, recognition, digit remembering, pattern recog-nition) of Risperidone group were higher than those of Chlorpromazine group, and the differences between the two groups were signifi-cant (P<0. 05). Conclusions: The effects of Risperidone on cognitive function and negative symptoms in the patients with chronic schizophrenia are better than those of chlorpromazine.