血浆尾加压素Ⅱ在慢性阻塞性肺疾病的表达及其意义

摘要

Objective To observe the expression of plasma urotensinⅡ( UⅡ) in the patients with chronic obstructive pulmo-nary disease( COPD) , and to investigate the implication of UⅡ in the pathogenesis and progress of COPD.Methods Patients with COPD including the acute exacerbated COPD and the stable COPD and the healthy control subjects were recruited, Plasma UⅡ con-centration was measured by ELISA.The patients should undergo some exam inations, such as the pulmonary function, complete blood count,bloodgas.SAS6.12 statistical software was used to analyze the data.Results Plasma UⅡshowed a higher expression in acute exacerbated COPD patients than these in stable COPD patients,both highter than in the control subjects and there was statistical signifi-cance(P<0.01).and it was correlated negatively with FEV1.0%、FEV1.0/FVC%、PaO2.Conclusions The concentration of UⅡhas a trend of increase with the deteriorated change of COPD,and may play an important role in the pathogenic process of COPD,such as hypoxia, airway obstruction and inflammation.%目的：通过检测慢性阻塞性肺疾病（ chronic obstructive pulmonary disease ，COPD）患者血浆尾加压素Ⅱ（ uroten－sinⅡ，UⅡ）的水平，研究UⅡ与COPD病情的相关性，以及在COPD发病机制中的作用。方法选取COPD急性加重期、稳定期患者及健康人对照，采用酶联免疫吸附试验法检测血浆UⅡ水平，同时测定肺功能、血气分析、血常规等相关指标。采用SAS6．12统计软件行统计学分析。结果急性加重期组[（45．70±3．82）ng／ml]与稳定期组[（27．76±3．96）ng／ml]比较，血浆UⅡ水平升高，且均高于健康对照组[（14．48±2．38）ng／ml]，差异有统计学意义（P＜0．01），血浆UⅡ水平与FEV 1．0％、FEV1．0／FVC％、PaO2呈负相关。结论 UⅡ随COPD患者病情的加重而增加，有可能参与COPD缺氧、气道阻塞及炎性反应的病理生理变化，导致COPD病情进一步恶化。