Objective:To investigate the epidemiology of disease in 2007-2017 children Kawasaki clinical features and risk factors associated with coronary artery lesion investigation.Method:The clinical data of 54 cases of Kawasaki disease in our hospital from January 2007 to July 2017 were retrospectively analyzed.Collate the information collected from the children's questionnaire after admission,according to whether they were complicated with coronary artery disease,they were divided into complications group and non complication group.The clinical characteristics and risk factors of coronary artery disease were analyzed.Result:Among the 54 cases,41 cases(75.93%) were male and 13 cases(24.07%) were female.The main clinical manifestations were fever (92.59%),limb changes(87.04%), rash(72.22%),conjunctival changes(88.89%),lip and oral mucosa changes(90.74%),cervical lymph node enlargement(35.19%) and perianal peeling(38.89%).The complication rate of coronary artery disease was 64.81% (35/54),and the total effective rate was 94.44%(51/54).The gender,white blood cell count,duration of fever and clinical diagnosis between two groups were compared,the differences were not statistically significant(P>0.05),the levels of C-reactive protein,erythrocyte sedimentation rate and platelet in complication group were higher than those of non complication group,and the levels of albumin and age were lower than those of non complication group,the differences were statistically significant(P0.05),并发症组C反应蛋白、红细胞沉降率、血小板均高于非并发症组,年龄、白蛋白水平均低于非并发症组,比较差异均有统计学意义(P<0.05).结论:川崎病临床表现具有一定的特征性,并发冠状动脉病变率较高,患儿年龄<3岁、C反应蛋白、血小板及红细胞沉降率水平升高及白蛋白水平降低均是川崎病并发冠状动脉病变的影响因素,监测上述指标水平变化利于医师诊断与治疗川崎病,改善患儿的预后.
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